Biotechnology, Rochester Institute of Technology Junior Postdoctoral training (2 years), Maastricht University, The Netherlandsī.S. in Biological Sciences, University of Cambridge, UK Medical Scientist MD/PhD Training Program.Biomedical Sciences PhD Training Program.Molecular and Cellular Pharmacology PhD Program.Division Head for Translational Research.School of Medicine, Division of Cardiology I also co-direct the Consortium for Fibrosis Research & Translation (CFReT) Our lab emphasizes teamwork and camaraderie, thus creating an exciting environment for students and postdoctoral trainees. As such, our lab has established core expertise to enable in vitro, cellular and in vivo assessment of experimental small molecule compounds in support of early stage drug discovery. and is associated with a 5-year mortality rate of nearly 50%. The long-term goal of our work is to translate basic discoveries to novel therapies for patients with heart failure, which afflicts millions of adults in the U.S.
We are also interested in the mechanisms whereby signals derived from cell surface receptors are conveyed to histone-modifying enzymes by proteins kinases and phosphatases. Our animal model studies involve echocardiographic and catheter-based measurements of heart function. We use molecular biology, biochemistry and pharmacology to address the roles of these and other epigenetic modifiers in the control of gene expression in the heart, and extend our findings to surgical, transgenic and gene knockout models of heart failure. Among the enzymes that target histones are histone deacetylases (HDACs), histone acetyltransferases (HATs) and histone methyltransferases. Nuclear DNA is wound around proteins called histones to form chromatin, and post-translational modification of histones represents one epigenetic mechanism for altering gene expression. We are particularly interested in the role of epigenetics in regulating the pathological cardiac hypertrophy and fibrosis that is associated with heart failure. Our lab is focused on understanding the signaling and gene regulatory mechanisms that control heart failure and associated disorders.
Adult Congenital Heart Disease Fellowship.Advanced Heart Failure, MCS/LVAD & Transplant
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